Marina M.L., Rios A., Valcarcel M. (Eds.) Analysis and Detection by Capillary Electrophoresis

Elsevier Science, 2005. — 767 р. — ISBN: 0444517189.Comprehensive Analytical Chemistry XLVCapillary Electrophoresis (CE) is a powerful analytical technique used to separate compounds and is increasingly being used in routine analytical laboratories. Analysis and Detection by Capillary Electrophoresis presents developments enabling the enhancement of the detection sensitivity in CE, including the different strategies used to achieve sensitivity requirements.It describes techniques allowing sample preconcentration and sensitive continuous detection systems and looks at recent developments such as chiral analysis in CE and electrochemical detection in microchips. UV-Vis absorbance detection, as the most widely used detection system in CE, is also presented. Analysis and Detection by Capillary Electrophoresis delves into the practical approaches used in the field and will greatly benefit analytical chemists, as well as students, teachers, technical analysts, scientists and researchers involved in capillary electrophoresis.The first aim of this book is to show the state of the art of basic CE using modern approaches, beginning with the fundamentals (chapter 1) and separation modes (chapter 2). The importance of preliminary operations in CE is shown in two chapters, one devoted to on-line
sample preconcentration techniques (chapter 3) and the other to coupling flow systems for both homemade and commercially available CE instruments (chapter 4). Because continuous detection is one of the aspects of CE that need to be improved, many scientists have devoted much effort to finding better detection alternatives. The second and more extensive part of the book is devoted to this hot topic. Molecular absorption and emission detection modes in CE, which can be considered the conventional ones, are dealt with in chapters 5 and 6, respectively, with attention focussed on the innovations in this context.
The use of detection techniques in CE based on phosphorescence and chemiluminescence, which are also molecular emission spectroscopic techniques, is described in chapter
7. In addition, chapter 11 is devoted to vibrational spectroscopy detection in CE, which can be considered as an emerging alternative. The growing importance of electrochemical detection in CE justifies its inclusion in chapter
8. The so-called hyphenated techniques involving CE are also of great importance; chapter 9, 10 and 12 devoted to mass spectrometric detection, optical emission ICP-MS detection and NMR detection, respectively, constitute an excellent overview of the present and future of detection in CE. Finally, the third part of the book is devoted to recent developments in CE. One chapter is devoted to the emerging and almost consolidated chiral separations in CE (chapter 13), and the other to electrochemical detection in CE as implemented in microchips (chapter 14).