Rossi D.T., Sinz M.W. (Eds.). Mass Spectrometry in Drug Discovery

CRC Press, 2002. - 429 p. Marcel Dekker. Mass Spectrometry in Drug Discovery summarizes the theory, instrumentation, techniques, and application of mass spectrometry and atmospheric pressure ionization to screening, evaluating, and improving the performance and quality of drug candidates. It provides time- and cost-efficient approaches for the generation and analysis of effective pharmaceuticals, covers advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing, and demonstrates the use of mass spectrometry in the assessment of disease states, drug targets, and potential drug agents.The Demand for Drug Discovery Today
The Impact of Atmospheric Pressure IonizationInstrumentation
A Mass Spectrometry PrimerExperimental Strategies
Ion Chemistry and Fragmentation
The LC/MS Experiment
Sample Preparation and Handling for LC/MS in Drug DiscoveryApplications
Mass Spectrometry in Combinatorial Chemistry
Drug Hydrophobicity and Transport
The Mass Spectrometer in Drug Metabolism
Mass Spectrometry-Assisted Applications of Stable-Labeled Compounds in Pharmacokinetic and Drug Metabolism Studies
Cassette Dosing in Drug Discovery
Applications of Microdialysis/Mass Spectrometry to Drug Discovery
Future Directions for Mass Spectrometry in Drug Discovery