Cotter R.J. Time-of-Flight Mass Spectrometry: Instrumentation and Applications in Biological Research

An American Chemical Society Publication, 1997. — 326 р.This book presents the basic principles of time-of-flight (TOF) mass spectrometry with a strong emphasis on applications in biological research. It describes many innovative techniques, including orthogonal extraction, post source decay, and delayed extraction, and surveys ionization techniques used on TOF mass spectrometers such as electron impact, plasma desorption, SIMS, FAB, laser desorption, MALDI, and electrospray. The book features chapters on applications to peptides/proteins, oligonucleotides, and other biological macromolecules, and examines how techniques might be used in sequencing the human genome.About the AuthorForeword
Overview and History
Time-of-Flight Mass Spectrometers
Reflectrons and Other Energy-Focusing Devices
Plasma Desorption Mass Spectrometry
SIMS Instruments
Laser Desorption and MALDI
Pulsed Extraction, Continuous Ionization, and Ion Storage Instruments
Product Ion Mass Spectra from Reflectron Instruments
Tandem TOF and Hybrid Instruments
Peptides, Proteins, and Glycoproteins
Oligonucleotides and the Human Genome
Summary and Future Prospects