Cazes J., Scott R.P.W. Chromatography theory

Marcel Dekker, Inc. , 2002. – 475 p.
Chromatographic separations involve a large number of interacting variables that must be optimized in order to achieve the maximum resolution and the minimum analysis time for any given separation. To select the best conditions it is ncessary to understand chromatography theory. A rational theory that quantitatively described a chromatographic separation was first put forward in the mid-1940s. It was further developed during the 1950s and, except for some minor additions, was complete by 1960. Since that time, much work has been reported supporting the fundamental relationships that were established. This book provides the basic theory of gas and liquid chromatography together with the foundations of thin layer chromatography. The thermodynamic and dynamic principles of chromatographic retention are considered in detail and the kinetic processes that lead to band dispersion are quantitatively developed for all three major chromatographic techniques. The factors effecting the efficacy of preparative chromatography are reviewed and a discourse on moving bed and simulated moving bed chromatography is included. In addition, the column design and the design of chromatographic equipment are also discussed.
The book has been written in such a way that the mathematical skills required to understand the arguments are reduced to a minimum. Although, the algebra is occasionally lengthy, the contents of this book will be easily understood by undergraduate scientists who have taken basic courses in algebra and calculus.
This book is directed to analysts who utilize chromatographic techniques on a routine basis, scientists interested in designing chromatographic equipment, graduate students and postgraduate research fellows, and all who wish to have a fundamental understanding of the processes involved in chromatographic separation.The mechanics of retention: introduction to chromatography theory
The control of chromatographic retention and selectivity (the Plate theory)
The distribution coefficient and its control of solute retention
The theory of mixed phases in chromatography
Programming techniques
Extensions of the Plate theory.
The mechanics of dispersion: the dynamics of peak dispersion
The rate theory equations
Extra-column dispersion
Exeprimental validation of the Van Deemter equation
The measurement of solute diffusivity and molecular weight
Chromatography column design
Chromatography column design - the design of open tubular columns for GC.