Wiley-VCH, 2007. - 345 p.
The introduction of the matrix-assisted laser desorption ionization technique (MALDI) changed mass spectrometry (MS) into a powerful tool for biomedical analysis that is now widely employed in academic as well as industrial laboratories.
The 2002 Nobel Prize was awarded for the development of methods for identification and structure analyses of biological macromolecules. MALDI is one of the two mass spectrometric methods besides Electrospray which is universally used for this purpose.
This unique book gives an in-depth description of the many different applications of MALDI MS, along with a detailed discussion of the technology itself. It will be a much-needed practical and educational asset for individuals, academic institutions and companies in the field of bioanalytics.
The MALDI Process and Method
MALDI Mass Spectrometry Instrumentation
MALDI-MS in Protein Chemistry and Proteomics
Microprobing and Imaging MALDI for Biomarker Detection
MALDI-MS of Nucleic Acids and Practical Implementations in Genomics and Genetics
MALDI-MS of Glycans
MALDI-MS of Lipids
MALDI-MS for Polymer Characterization
Small-Molecule Desorption-Ionization Mass Analysis